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Key points Leg cramps (especially calves and feet) are most commonly reported Nighttime cramps and post-exercise cramps appear most frequently Duration typically ranges from seconds to minutes per episode Intensity varies from mild discomfort to painful spasms that wake patients from sleep Managing muscle cramps Most Mounjaro-related muscle cramps can be effectively managed with simple strategies

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Melaena Stages Melaena can be classified into different stages based on the severity of bleeding and the duration of symptoms: Stage 1: Mild bleeding, which may appear as streaks or small clots in the stool

GLP-1 therapy is contraindicated in patients with personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, uncontrolled diabetes, or severe renal impairment