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How GLP-1 agonists work Multiple mechanisms: Slow gastric emptying (food stays in stomach longer, you feel full longer) Signal satiety to brain (reduce hunger at neurological level) Improve insulin sensitivity (better blood sugar control) Reduce cravings (especially for hyperpalatable foods) May increase metabolism slightly Why they're so effective: They address the biological drivers of overeating, not just willpower

6.6 Acute single ingestion The timing of the presentation is critical in determining the management approach

This effect is mediated through its role as a precursor to L-cysteine (Aldini et al

The oesophagus is separated from the pharynx by the upper oesophageal sphincter (UOS), which is normally closed due to tonic activity of the nerves supplying the cricopharyngeus