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Combining two incretin-based therapies creates dangerous overlapping receptor activation

They are pathway-level markers that do not predict response to a specific drug, but they add context that a prescription alone, from any GLP-1 program, does not capture

Inoue A, Kikuchi S, Hishiki A et al (2014) A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin

Clinically developed GLP-1 therapies amplify these effects, offering a science-backed approach to metabolic health