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[39] Depletion of liver glutathione levels (the site of glutathione storage) may be devastating to health

The efficacy of probucol combined with hydration in preventing contrast-induced nephropathy in patients with coronary heart disease undergoing percutaneous coronary intervention: a multicenter, prospective, randomized controlled study

However, patients with HCC often develop resistance to TKIs and this resistance development is associated with increased IGFBP-1 expression, the aggregation mechanism manifested by TKI-induced hypoxia increasing IGFBP-1 expression through activation of HIF-1 and HIF-2