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The activation of the PI3K/AKT signaling pathway and the induction of mTOR is involved in the regulation of several glycolysis-related rate-limiting enzymes expression that is mainly dependent on HIF-1 activity and stability have also been proposed by previous studies (91, 92)

However, persistent or severe diarrhoea warrants medical attention, as it may lead to dehydration and electrolyte imbalances

High GH and high IGF-I One of the most well-described primary GH disorders of high GH and high IGF-I is acromegaly (66)

[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Akbaraly J.P., Leng J.J., Bozler G., Seydel J.K