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NICE guidance including Technology Appraisal TA875 (semaglutide 2.4 mg for managing overweight and obesity), Clinical Guideline CG189 (Obesity: identification, assessment and management), and Public Health Guidance PH53 (Weight management: lifestyle services for overweight or obese adults) recommends a structured, tiered approach to weight management

University of Washington Diabetes Institute

Key Takeaways If youre asking why GLP-1 isnt working or why GLP-1 doesnt work, the reasons may include unrealistic expectations, lifestyle factors, dosage, or underlying health conditions

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