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Compared to traditional PR antagonists, SPRMs offer the most significant advantage of tissue selectivity, enabling targeted therapeutic effects on diseased tissues while minimizing non-specific impacts on healthy tissues

The mRNA levels of PTGS2 were 89 times higher in both normal and cancerous tissues from patients with CRC compared with those in healthy individuals

Elderly patients, who are more prone to malnutrition, may need preoperative nutritional support or even surgery delays if severe deficiencies are identified [16]

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