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c-Myc transcriptionally binds to the promoter region of glutamine importers, ASCT2 and SN2, leading to increased glutamine uptake and tumor progression

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Some studies conducted in rodents, with exanatide and liraglutide, showed an association regarding the development of thyroid C-cell tumors after long exposures to overtherapeutic doses ( in vivo studies in cynomolgus monkeys administering liraglutide showed no effect on the relative fraction of C cells in the thyroid gland after 87 weeks

The epidemiological studies reveal that in the year 2010 it is expected that there will be around 1.1 million new cases of GC and that about 60% of new GC cases will be in developing countries