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doi:10.1186/s12933-014-0129-4

In the context of severe intestinal lesions such as the crypt loss observed in inflammatory bowel disease (IBD), LGR5 + intestinal stem cells (ISCs) vigorously proliferate and differentiate to replenish the cellular pool essential for restoring the epithelial barrier, thus promoting epithelial regeneration post-injury 1,2

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