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In the setting of widespread availability of excess calories and more sedentary lifestyles 2,3,4,5 as exists in much of the modern worldmechanisms that reduce muscle mass to conserve energy are counter-productive, and unfortunately result in higher fat deposition and obesity, and can exacerbate the risk of sarcopenia 6

Glucagon receptor activation can increase energy expenditure and may promote fat use, but it can also raise glucose in some contexts, which is why the balance of the three pathways matters

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NIH Office of Dietary Supplements L-Carnitine Fact Sheet for Health Professionals