After successfully losing 40 pounds using Semaglutide and Tirzepatide, Amanda understands the journey firsthand
In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms

Contact your GP or diabetes specialist if you experience: Severe, persistent abdominal pain (especially if radiating to the back), which could indicate pancreatitis Signs of dehydration (excessive thirst, dry mouth, reduced urination, dizziness) Persistent or severe gastrointestinal symptoms Symptoms of hypoglycaemia (if also taking insulin or sulfonylureas) Muscle weakness or cramping Irregular heartbeat or chest pain Confusion or significant fatigue Worsening diabetic retinopathy symptoms Any concerns about your diabetes management or medication regimen Always inform your healthcare team about all supplements you are taking to ensure safe and effective diabetes care
As in North Carolina, more than 70% of West Virginia residents are overweight or obese