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Indirect antioxidants restore cellular redox balance and safeguard biomolecules from oxidative stress by activating the Nrf2-Keap1/ARE pathways and inducing the expression of glutathione synthesis, superoxide dismutase (SOD), catalase, and GPx or peroxiredoxins ( 3.2 Hormonal modulation and estrogen receptor interactions Hormonal modulation and ER interactions is perhaps the most extensively investigated mechanistic axis through which natural supplement act on breast cancer biology considering estrogen signalling being the main agent for carcinogenesis, progression and therapeutic resistance especially in HR positive subtypes that comprise almost 70% of total breast cancer patients worldwide (184)

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