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In terms of preventing adverse outcomes, periconceptional folic acid supplementation has a proven role, established more than 30 years ago, in protecting against neural tube defect-affected pregnancies and this has been the major focus of public health policy worldwide

It can support a small, additional weight loss when combined with diet and exercise, based on randomised trials

66 (Tables 1 and 2) Current GLP-1RAs GLP-1RAs are synthetic protein preparations that have partial or complete amino acid sequence homology with GLP-1 found in the body, are not easily degraded, have longer half-lives and have stronger biological activity

Weight loss is a multifaceted outcome influenced by diet, physical activity, sleep, stress, appetite, and adherence over time