ghrelin and glp-1 How gut hormones shape reward:

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A 104-week carcinogenicity study was conducted in male and female Sprague Dawley rats at doses of 0.075, 0.25 and 0.75 mg/kg/day liraglutide administered by bolus subcutaneous injection with exposures 0.5-, 2- and 8-times the human exposure, respectively, resulting from the MRHD based on plasma AUC comparison

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BBS is a very rare genetic ciliopathy with multisystem manifestations, commonly including early-onset obesity and hyperphagia