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R 11 is H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, C 2 -C 7 heterocycloalkyl, C 6 -C 10 aryl, C 3 -C 9 heteroaryl, C 1 -C 6 alkylC 3 -C 6 cycloalkyl, C 1 -C 6 alkylC 6 -C 10 aryl, or C 1 -C 6 alkylC 3 -C 9 heteroaryl

The primary processes of paraquat toxicity involve the production of reactive oxygen species and the cellular release of nicotinamide adenine dinucleotide phosphate (NADPH) 27

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The aim of this trial is to evaluate longer term safety and efficacy of OCA for improvement of NASH and fibrosis