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In vivo, extracellular KYNA inhibits NMDA- and QA-induced excitotoxic depolarizations in the rat cortex, demonstrating that KYNA accumulation can protect neurons not only via NMDAR antagonism but potentially through additional molecular targets [87]

No controlled trial has evaluated GLOW as a blend

Phase 1 (Weeks 1 to 2): 0.25 mg subcutaneous injection once daily, morning on empty stomach Phase 2 (Weeks 3 to 6): Maintain 0.25 mg or increase to 0.5 mg based on response and tolerance Phase 3 (Weeks 7 to 8): Continue or begin taper depending on symptom improvement Maintenance: Consider cycling 4 weeks on, 2 weeks off for long-term management Oral dosing requires higher amounts to compensate for bioavailability differences

The Lancet Gastroenterology and Hepatology , 1 (3), 226237