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The REDEFINE 1 Phase 3 trial demonstrated 20.4% mean weight loss at 68 weeks in 3,417 participants, and Novo Nordisk has filed an NDA with the FDA

We did not note colonic intestinal inflammation in PUFA WD- or AA/FM-exposed Gpx4 +/IEC mice, suggesting that environmental cues may determine disease localization

For instance, nobiletin, a citrus flavonoid, can bind ROR nuclear receptors and has been shown to enhance circadian amplitude and improve metabolic syndrome in mice by acting on clock gene regulation (He et al., 2016)