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There are also examples of oral medications that when being used experimentally via inhalation cause significant toxicity, such as the death of a research participant following inhalation of hexamethonium [104]

NCTC1469 cells, a normal mouse hepatocyte cell line, were obtained from the American Type Culture Collection and were cultured in DMEM containing 10% (v/v) fetal horse serum, 2 mM glutamine, 5 U/mL penicillin, and 50 g/mL streptomycin at 37 C in a humidified O 2 /CO 2 (19:1) atmosphere

Pharmacovigilance Surveillance The PV surveillance team compiles data into Development Safety Update Reports (DSURs) to determine if a drug should proceed to the next phase of research

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