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Doses Per Vial Vial duration varies by dose escalation phase: 3mg vial: At 0.25mg/week = 12 weeks At 0.5mg/week = 6 weeks At 1mg/week = 3 weeks At 2.4mg/week = 1.25 weeks 5mg vial: At 0.25mg/week = 20 weeks At 0.5mg/week = 10 weeks At 1mg/week = 5 weeks At 1.7mg/week = ~3 weeks At 2.4mg/week = ~2 weeks A 5mg vial can cover the entire first 4 months of a slow escalation protocol starting at 0.25mg

It Has Clear Performance-Enhancing Potential

It is seronegative, meaning unlike rheumatoid arthritis, it does not produce a positive rheumatoid factor on blood testing

(b) Methodology To Estimate the Cost Performance Category Score We estimated the cost performance category score using a methodology similar to the methodology described in the CY 2025 PFS final rule (89 FR 98531) for the baseline and the proposed policies RIA models with the modifications described later in this section