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Evidence implicates the leptin axis in decreased cardiomyocyte contractility and through nitric oxide, B-adrenergic intermediates, reactive oxygen species, ceramide, and pro-inflammatory factors

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The study also found that adults taking a GLP-1 had an increased risk for interstitial nephritis, a type of kidney condition that Al-Aly says is almost like an allergic reaction that the kidney mounts against certain drugs. He says more long-term studies are needed to better understand the risks and benefits of prolonged use

Sci Rep (2019) 9:12986