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Approximately half of those who had discontinued treatment had reinitiated treatment within 3 years after discontinuation, such that the proportion of patients who had ongoing treatment (proportion of patients covered) was approximately 7080% for both drugs during a 15 year period after treatment initiation

~6 days Half-Life (NEJM 2023) ~30 days Full Clearance (5 half-lives) 4-5 weeks Steady State Per Dose Once Weekly Dosing Interval Investigational Status Retatrutide is investigational and not FDA-approved as of April 2026

On the other hand, we observed an increase in the depleted expression of Glut-4 protein in both tissues of GK rats, indicating increased glucose uptake (Figure 8B)

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