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That structural feature is significant: proline residues resist proteolytic cleavage, making the peptide unusually stable in gastric conditions relative to most short peptides [1]

Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function

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Inflammopharmacology (Springer) 2026