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While effective for short-term weight loss, it comes with significant drawbacks: Only FDA-approved for short-term use (up to 12 weeks) Can cause increased heart rate, anxiety, and insomnia Has addictive potential as a Schedule IV controlled substance Weight regain is common after stopping the medication Topamax (Topiramate) Topiramate is an anticonvulsant that has been prescribed off-label for weight loss due to its ability to suppress appetite

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Numerous studies have revealed the physiological functions of the BBB such as brain protection