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The researchers noted that "acute ingestion of SPB [Setria Performance Blend]* after eight days may enhance blood flow, L-citrulline, and L-arginine plasma concentrations after high-intensity exercise, which may enhance performance." *Setria Performance Blend is now referred to as Setria for Sport This study demonstrates the specific benefits for endurance athletes, especially in terms of improved blood flow, oxygen delivery, and recovery capacity following high-intensity exercise

Phase I pilot (three healthy male volunteers, subcutaneous administration, 1996, PMID 8637402), increased facial, upper-body, and buttock pigmentation persisting approximately one week after cessation of dosing was reported alongside nausea and somnolence