Comparative metabolic and hepatic effects of GLP-1-based mono-, dual-, and triple-agonist therapies GLP-1 receptor signaling Intestinal L-cells serve as the primary source of GLP-1 synthesis, which operates via G-protein coupled receptors present in pancreatic beta cells, gastrointestinal and central neural systems, cardiac tissues, and kidneys [26]
According to the researchers, this may be because sense of taste is only one factor involved in weight loss
Additionally, most mechanistic studies rely on animal models, raising concerns about translatability to humans due to interspecies differences in GLP-1R distribution and signaling (Drucker, 2022)
Alli can be a helpful short-term aid to support weight loss, but long-term success depends on sustaining changes to eating habits, activity levels and overall lifestyle