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aeruginosa commonly uses low-permeability outer membranes, active efflux, and enzyme production simultaneously to resist multiple drug classes

Theres evidence that polyunsaturated fatty acids like linoleic acid may act directly and indirectly on 5-alpha reductase by 1) reducing inflammation, and 2) altering lipid bilayers in cell membranes to decrease 5-alpha reductase formation

J Clin Invest 109 : 857862 Graveel C, Su Y, Koeman J, Wang LM, Tessarollo L, Fiscella M, Birchmeier C, Swiatek P, Bronson R, Vande Woude G (2004) Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele

The GLP-1 drugs in the study which included semaglutide (sold as Wegovy and Ozempic), liraglutide, dulaglutide, and exenatide have skyrocketed in popularity in recent years for weight loss and blood sugar control