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Description

Researchers observed notable benefits, such as improved blood sugar control and weight loss in individuals

Studies have shown that inhibition of the PI3K-AKT signaling pathway reduces insulin sensitivity by degrading Sort1, a component of GLUT4 storage vesicles [199]

Of greater clinical significance are potential safety concerns that require further investigation in larger trials: Heart rate elevation glucagon is known to have chronotropic effects, and increases in resting heart rate were observed in some trial participants