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The magnitude of liver fat reduction exceeded predictions based solely on weight loss, suggesting direct hepatic effects beyond indirect benefits of fat mass reduction

Because retatrutide remains pharmacologically active for an extended period, any adverse effects experienced may also persist for a corresponding duration

A 48-week Phase 2 trial reported in The Lancet in 2025 showed mean weight reduction ranging from approximately 9% at the lowest dose to 20% at the highest dose, compared with 0.4% on placebo

GLP-1 slows stomach emptying, reduces appetite, improves insulin sensitivity, and helps regulate blood sugar