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this result is similar to the findings shown in Figure 1e, right column ( bars 8 and 9 , missing the wash-out step)

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Yellowing of the skin or the whites of the eyes (jaundice)

Moreover, a randomized, evaluator-blinded clinical trial including 40 Brazilian women with facial melasma who underwent broad-spectrum tinted sunscreen and nightly application of 5% cysteamine or 4% HQ for 16 weeks resulted in an MASI reduction of 32% and 52%, respectively [31]