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Unfavourable effects of tesaglitazar are dose dependent and may include undesired weight gain, increased serum levels of creatinine and decreased glomerular filtration 13,17,19,20

GSK is paying $500 million upfront to get the ball rolling on the alliance, claiming rights to the first programme, a PDE3/4 inhibitor codenamed HRS-9821 in clinical development for the treatment of chronic obstructive pulmonary disease (COPD), outside China and some of its territories

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