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These large growing follicles were enumerated independently and in combination: all antral being small, large antral and pre-ovulatory

GI side effects during escalation vs maintenance Both compounds share an important characteristic: most gastrointestinal side effects occur during dose escalation, not during maintenance

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On the other hand, hypoxia-induced vascular endothelial growth factor (VEGF) type 2 receptor (VEGFR-2) pathway activation, increasing permeability in the brain microvascular endothelium by decreasing junctional proteins claudin-5, occludin, and ZO-1 (Castaeda-Cabral et al., 2020)