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The tradeoffs are equally real: weekly injection, $900+ per month without insurance, limited supply relative to demand, and side effects that affect a substantial portion of users nausea, vomiting, constipation, and GI disruption are among the most common, particularly during dose escalation

Avoid greasy, spicy, or fatty foods, which can worsen nausea

However, this interaction was not required for small molecule agonist TT-OAD2 that elicited cAMP signaling without the presence of an ECD 14