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While human clinical trials remain limited, the extensive body of animal research suggests potential applications in gastrointestinal healing, tendon and ligament repair, muscle recovery, neuroprotection, and cardiovascular health

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For instance, a review we conducted at this time of ClinicalTrials.gov.org using NAD + as other term input and the following precursors as intervention reveals that there are 4 clinical trials investigating NA, 7 trials focused on NAM, 8 trials administering NAD + , 16 trials studying NMN, and over 60 trials exploring NR with NAD + measurements included as readout

Intervention studies consistently show that supplementation with folic acid, particularly alongside vitamins B6 and B12, lowers homocysteine regardless of MTHFR genotype