how to ship semaglutide VisualAbstract: Once-weekly Reduces Body Weight in People with Obesity OZEMPIC PEN 0.25MG (2MG/3ML), 3ML

2T2DM -1GLP-1GLP-1RGLP-1RGLP-1GLP-1GLP-1 +GLP-1GLP-1GLP-1 20251217GLP-1 GLP-1 -1GLP-1GLP-1RGLP-1RGLP-11983 , L GLP-1GLP-17-36GLP-17-37, 30GLP-17-36GLP-17-37GLP-1GLP-1RGLP-1GLP-1 GLP-1GLP-1 [1] GLP-14dipeptidyl dipeptidase-4DPP-4GLP-1RGLP-1DPP-4 GLP-1 DPP-4 GLP-1 GLP-1GLP-1RDPP-4GLP-1RDPP-4 GLP-1 GLP-1RDPP-4 GLP-1RDPP-4 GLP-1RDPP-4GLP-1RGLP-1 1-2 DPP-4GLP-1RDPP-4 [1] GLP-1R2GLP-1RGLP-1RGCGRGLP-2RGIPR GHRHRB1GPCRGLP-1RGGsGiGoGq/11GLP-1GLP-1RGs(AC)cAMPcAMPAPKAcAMP2Epac2 PKA ATP K+PKACa2+(VDCC) Ca2+Epac2Ras1Rap1CPLCIP3DAGCa2+GLP-1R [2] GLP-1 80%PEGFc / (Exenatide) FDA1GLP-1R392Amylin-PLGA1 (Bydureon)20112012FDA GLP-1DOEGLP-1 GLP-1 GLP-1AAALACGLP-like / :GLP-1 GLP-1 Cetagliptin50mg24DPP-480%GLP-1Cetagliptin D-GLP-1 GLP-1 GLP-1/PK PK Compound A Cmax AUC(0-t)0.04mg/kg 0.04 mg/kg Compound A83.17% GLP-1 2022930CDEOzempic-1GLP-1/221GLP-1 Ozempic GLP-1 2022829GLP-1105 I GLP-1GLP-1RCDE202320244-5 MDR-001 2023420CDEMDR-0012MDR-001AIMolecule ProGLP-1R202212FDAMDR-001ADMEbest-in-classMDR-001ADMEMDR-001HbA1CMDR-001GLP-1R GLP-1RGLP-1R CRO20 INDANDA NMPAIND US FDAIND/ANDA NMPAIND/ANDA [1] Baptist Gallwitz

American College of Cardiology/American Heart Association Task Force on Practice Guidelines, Obesity Expert Panel, 2013

Understanding the Variability of Results: Data Overview The data below represents average weight changes

Both outcomes improve metabolic health, but they are not interchangeable