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- Acta en el metabolismo de las grasas
In vitro experiments demonstrated that glutamate induced the enhanced levels of FTL, GPX4, and SLC7A11 in R28 cells, which were reversed through the administration of the inhibitor of p38 mitogen-activated protein kinase (MAPK) pathway (102)
Reactive metabolites from lipid peroxidation disrupt essential cellular structures, initiating cell death and DAMP releasea process further amplified by antioxidant depletion and exemplified in SLE, where neutrophils undergo ferroptosis and NETosis, activating TLR-dependent ROS generation that propagates inflammatory tissue injury (76, 87, 113115)
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