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For the treatment of obesity, GLP-1RAs and GIP/ GLP-1RAs are indicated in patients with a body mass index (BMI) 30 kg m 2 , or 27 kg m 2 in the presence of at least one weight-related comorbidity, to support weight reduction [23]

Actually, the unpublished data of our team indicates that acidosis can induce neural stem cell damage through excessive activated acid-sensing ion channels (ASICS), which are abundantly located on the dendritic spine of CSF-cNs

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