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Multiple experimental and clinical studies have demonstrated the beneficial effects of GA in CKD ( Recent evidence suggests that combining nephroprotective agents may offer enhanced efficacy compared to monotherapy ( 2 Materials and methods 2.1 Animals Male Wistar rats were obtained from the small animal house, Sultan Qaboos University (SQU), Oman, and housed in a room with a regulated environment (temperature 22 C 2 C, relative humidity approximately 60%, and 12 h lightdark cycle, with light at 6.00 a.m.), and they were fed a standard additive-free diet and tap water ad libitum

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