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Bru-seq nascent RNA profiling HCT116 cells (4 10 6 ) were treated with siGSTO1 (10 nM), DMSO or C1-14 (10 M) for 4 h or with C1-27 (1 M) for 4 and 24 h

We next measured the BP response to acute semaglutide using tail-cuff measurements in Glp1r VSM+/+ and Glp1r VSM/ mice across 3 distinct experimental models of hypertension: (a) addition of the nitric oxide synthase inhibitor L-NAME to the drinking water (Figure 2, GL), (b) AAV8-induced renin overexpression (Figure 2, MR), and (c) continuous Ang II infusion with s.c

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