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The resultant ionic imbalance triggers changes in intracellular osmotic pressure, leading to cellular swellingan important event in the execution of ferroptosis ( 3.2 Amino acid metabolic reprogramming 3.2.1 The central role of the glutamate-GSH pathway in ferroptosis Ferroptosis is highly dependent on GPX4-mediated reduction of lipid peroxides, and reduced GSH serves as GPX4s substrate

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Additionally, a new model that combines both the baseline MELD and 7-day Lille score demonstrated superiority over models relying solely on baseline data for predicting prognosis in SAH [13]