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Semaglutide is the active ingredient in several brand-name medications, including Ozempic and Rybelsus (approved for type 2 diabetes) and Wegovy (approved for chronic weight management)

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The handful of studies examining body composition showed promise, but sample sizes were small and duration limited

(Doses of Zepbound range from 5 milligrams to 15 milligrams.) Research on the effectiveness of semaglutide has also been positive: 175 subjects with overweight or obesity who took semaglutide lost an average of 5.9 percent of their body weight after three months (13 weeks) and 10.9 percent after six months (26 weeks