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This hypothetical adverse effect, although not clinically reported until now, is analogous to the hypothalamic-pituitary axis suppression seen with long-term use of systemic corticosteroids Exacerbation of Helicobacter pylori associated peptic ulcers: Helicobacter pylori is known to feed on macrophages and neutrophils abundant at the site of inflammation caused by the ulcer

10.1016/j.intimp.2015.02.002 111 LimaP., R.MeloT., S.CarvalhoK.OliveraI.ArrudaB., R.et al (2013)