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Indeed, researchers found that obese individuals have higher levels of mast cell-derived tryptase.[ref][ref] Taking this one step further, some researchers link increased inflammation due to mast cell activation in adipose tissue to the cause of diabetes

However, the lack of human safety data, economic disincentives, and doping controversies underscore the challenges ahead

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2 The two dominant incretins are glucagon-like peptide-1 (GLP-1), secreted by enteroendocrine L cells (located in the ileum and colon), and glucose-dependent insulinotropic peptide (GIP), secreted by K cells (located mainly in the duodenum)