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The combination's popularity is based on the complementary nature of their individually studied mechanisms
In addition, when used with cisplatin, EGCG enhanced cytotoxicity and reduced kidney toxicity (El-Mowafy 2010)
More recently, it has been demonstrated that NSC-34 cells expressing TDP-43 mutants also exhibit shortened neurites, increased OS, and decreased HO1 level, and these effects can be reversed by the UPS inhibitor MG132, but not by the Nrf2 activator sulforaphane [255, 256], probably because MG132 induction of HO1 is Nrf2 independent
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