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All data on sex, date of birth, death, emigration, and socioeconomic factors were obtained from the Danish Civil Registration System

It had been shown that protein kinase R (PKR) was activated in the later stages of HSV-1 infection enhancing phosphorylation of eIF-2 (Chou et al., 1995) and inducing phosphorylation of endoplasmic reticulum resident kinase (pERK) (Cheng et al., 2005), thereby inhibiting protein synthesis (Poppers et al., 2000)

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