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Am J Physiol Regul Integr Comp Physiol (2000) 278(4):R105763

During pregnancy, you need more B12 because it gets stored by the placenta, which provides the fetus with enough of the vitamin to double moms B12 concentrations

Some examples found in various types of cancer are loss-of-function mutations of the iron-sulfur B subunit of the succinate dehydrogenase complex (SDHB) and fumarate hydratase (FH) with increased levels of fumarate and/or succinate (Haas and Nathanson, 2014