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Preventing Local Injection Site Reactions FDA labels for semaglutide and tirzepatide report injection-site reactions among possible adverse effects

Sertraline can cause nausea or appetite changes in some patients, while semaglutide commonly reduces appetite and may cause nausea, constipation, or diarrhea

In MC4R -deficient individuals, FTO risk allele carriers have significantly reduced weight loss efficacy after semaglutide treatment compared with those with normal genotypes, and the rate of weight regain in the later stage of treatment is significantly higher [79]

Two of three subjects who had insulin resistance at baseline showed normal insulin responsiveness at the end of the study, and highly sensitive C-reactive protein (hs-CRP, a marker of systemic inflammation) improved by a median of 25% among participants who showed clinical psoriasis improvement