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2019), Ammonia is released when glutamate is further converted to -KG by mitochondrial GLUD1

Covariates Participants underwent health examinations and interviews by well-trained medical staff

PNI was first reported in head and neck tumors and was subsequently researched in various tumors, including gastric cancer [5], breast cancer [6], prostate cancer [7]

When the gut lining is inflamed and permeable, neurotransmitter production is disrupted, inflammatory cytokines cross into systemic circulation and reach the brain, and the vagus nerve the primary communication cable between gut and brain transmits distress signals that manifest as anxiety, brain fog, and fatigue