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Initially, GLP-1 medication was developed to treat type 2 diabetes and, although it is effective, other significant weight loss benefits were also found , leading to their use as a weight management tool

Thus, direct NAD + administration may exhibit unique effects compared to NAD + precursors and modulators, warranting further investigation, especially given the rise of wellness and anti-aging clinics offering intravenous NAD + therapy, while clinical evidence is still scarce 119