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Glutamate-induced Ca 2+ influx and concurrent NO production act synergistically to impair mitochondrial function, further aggravating oxidative stress and cytotoxicity (Duchen 2004)
Expert Opin Pharmacother 8:279288 Jemiolo B, Harvey S, Novotny M (1986) Promotion of the Whitten effect in female mice by synthetic analogs of male urinary constituents
The long-term galactose adaptation might directly inhibit THF cofactor biosynthesis, providing additional means to buffer the defective mitochondrial THF import in the SLC25A32 KOs
They may include neurological problems, skeletal issues, vision and hearing loss, cardiovascular problems, and an increased risk of certain cancers
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