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These molecules can be derived from natural sources, including food, venoms, and marine organisms [16, 17], or synthesized through enzymatic hydrolysis and recombinant DNA technologies [18]

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142 Several conditions may also result in higher vitamin B 12 concentrations in critically ill patients, especially in older adults, such as preexisting diseases (eg, renal failure, hepatic diseases, cancer, Alzheimers disease), nutritional status, and inflammatory status (eg, sepsis)